As we grow older, our cells face new challenges that can affect energy, recovery, and overall vitality. This has led many people to explore supplements that target ageing at its roots.
Two of the most talked-about options are NAD+ boosters and resveratrol, both of which play important roles in cellular health.
NAD+ (nicotinamide adenine dinucleotide) is a molecule essential for turning food into energy and supporting repair processes. If you’re unfamiliar with it, we’ve covered the basics in our guide on what is NAD+.
Resveratrol, on the other hand, is a plant compound found in grapes and berries, best known for its antioxidant and longevity-linked properties.
When taken together, these two compounds may work in synergy to support healthy ageing, a combination that researchers and wellness experts are increasingly interested in.
What is NAD+ And Why Is It Important?
NAD+ is found in every cell in the body. It plays a vital role in converting food into energy, repairing damaged DNA, and maintaining cell function.
It also supports the mitochondria, the “powerhouses” of our cells which generate most of the energy we need for daily life.
Unfortunately, NAD+ levels decline with age.
Research has linked this drop to reduced energy, slower recovery, and other signs of ageing [1]. Scientists are now investigating ways to restore NAD+ as a strategy for healthy ageing.
This is where NAD+ boosters come in.
Compounds such as NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are precursors to NAD+.
They provide the building blocks the body needs to produce more of it. Studies in both animals and humans suggest that supplementing with NMN or NR may improve energy metabolism and support cellular health [2][3].
If you’d like to dive deeper, we’ve explored this in detail in our article on NMN benefits.
NMN Supplement by Naturecan
Designed to support overall health and well-being, incorporating our pure NMN supplement into your daily regimen is an excellent choice for anyone looking to enhance their wellness and longevity journey.
- 500mg of NMN (Nicotinamide mononucleotide) per capsule
- Premium capsule technology
- May increase lifespan
- Two month supply of capsules
- NAD+ Booster
- Suitable for vegans
NAD Supplement by Naturecan
Taking NR as a supplement may boost NAD+ levels, supporting your body’s natural repair and energy systems.
This boost might help with brain function, immune health, and overall energy. Although research is still ongoing, early studies suggest that NR may support healthy ageing.
- 90 Servings of premium Nicotinamide Riboside (NR, 90 day supply)
- 300 mg NR per serving (1 capsule per day)
- Scientifically supportive ingredients
- Vegan
- Made in Germany
What is Resveratrol?
Resveratrol is a natural compound found in grapes, blueberries, peanuts, and red wine. It is often studied for its role in supporting healthy ageing.
One reason resveratrol is interesting is because it can activate sirtuins. These are proteins that help cells repair DNA, resist stress, and regulate metabolism [4].
Resveratrol also works as an antioxidant.
Antioxidants protect the body from oxidative stress, which occurs when harmful molecules called free radicals accumulate in cells [5].
Over time, oxidative stress can damage cells and contribute to ageing.
Studies suggest that resveratrol may support heart health, brain function, and inflammation balance. Most of this evidence comes from animal studies and early human trials, so more research is still needed [6]. For more details, see our article on resveratrol benefits.
Featured Supplement: Resveratrol
Our Resveratrol supplements are designed to support your cardiovascular health and overall well-being. Hence, incorporating our pure Resveratrol capsules into your daily regimen is an excellent choice for anyone looking to enhance their wellness journey.
NAD+ and Resveratrol: Why Combine Them?
On their own, NAD+ and resveratrol are valuable. But together, they may have a stronger effect.
- NAD+ is the fuel. Sirtuins, the proteins linked to ageing and repair, cannot function without NAD+.
- Resveratrol is the switch. It helps to “activate” sirtuins so they can do their job [7].
When NAD+ levels are supported through NMN or NR, and resveratrol is present to activate sirtuins, the process works more efficiently.
Think of a car: NAD+ provides the fuel, while resveratrol turns the ignition key. Both are needed to get the engine running smoothly.
This synergy has been highlighted in research led by Dr David Sinclair at Harvard University, which showed that resveratrol activates sirtuins, but these proteins also require NAD+ to function effectively [8].
What Supplements does David Sinclair Take?
Discover the supplement stack reccomended by Dr David Sinclair himself.
Read More5 Potential Benefits of Taking NAD+ and Resveratrol Together
When combined, NAD+ and resveratrol may support several aspects of health. While the current research is promising, most findings come from animal and early human studies, so more work is needed before firm conclusions can be made.
Five potential benefits include:
- Supports cellular energy: NAD+ drives energy production in mitochondria. Resveratrol may help regulate this process. Together, they could promote efficient energy use in cells [9].
- Aids DNA repair: NAD+ provides the resources for DNA repair, while resveratrol activates the proteins that regulate it. This may strengthen cellular defences [10].
- Promotes healthy ageing: Declining NAD+ is linked with age-related changes. Resveratrol activates longevity pathways through sirtuins. The combination may help maintain resilience with age [11].
- Protects against oxidative stress: NAD+ supports antioxidant enzymes, while resveratrol acts directly as an antioxidant. Together, they may reduce damage caused by free radicals [5].
- Supports metabolic health: NAD+ is involved in glucose and fat metabolism. Resveratrol has been linked to improved metabolic function. Together, they may support balanced metabolism [4].
Featured Bundle: NMN & Resveratrol
Boost your well-being with Naturecan's NMN and Resveratrol bundle. Designed to support energy and longevity, this powerful combination goes beyond conventional supplements by pairing two scientifically backed ingredients known for their potential to combat ageing and promote cellular health.
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How to Take NAD+ and Resveratrol Together
If you want to include NAD+ boosters and resveratrol in your wellness routine, here are a few points to keep in mind.
Timing
Morning use: Many people prefer to take NAD+ boosters such as NMN or NR in the morning to support natural energy rhythms. Resveratrol may also be taken in the morning with food.
This can help improve absorption and provide antioxidant support during the day, when the body faces oxidative stress.
Some studies suggest that morning use may also support energy and reduce inflammation, which can be useful for those who are physically active [12].
Evening use: Others choose to take resveratrol at night. Research indicates it may influence melatonin production, which could support better sleep and overnight cellular repair.
Night-time intake is also associated with potential benefits for cardiovascular health, as the body focuses on repair during rest [6].
The best timing may depend on your goals. Morning use may be suited for energy and daily resilience, while evening use may support sleep and recovery.
Format
- Capsules: The most common and convenient option for daily use. They provide consistent dosing and are easy to include in a morning or evening routine.
- Powders: Supplements like NMN powder can be mixed into water, smoothies, or other drinks. This format offers flexible dosing and may appeal to those who prefer not to take capsules.
- Sublingual forms: Some NAD+ boosters are available as sublingual powders or lozenges. These are placed under the tongue, where they are absorbed directly, potentially improving bioavailability [2].
- Combination stacks: Some people prefer to take NAD+ boosters and resveratrol separately, while others combine them into a personalised longevity stack. Pairing the two can be done with individual products, depending on goals and convenience.
At Naturecan, we offer a range of products designed to work together: NMN supplements, NR capsules, and resveratrol supplements.
Should You Take Them?
NAD+ boosters and resveratrol are popular in the longevity space because they target the same cellular pathway. NAD+ provides the fuel for sirtuins, while resveratrol helps to switch them on.
Together, they may support processes linked with healthy ageing [8].
These supplements are not a quick fix.
Lifestyle factors such as sleep, diet, and exercise remain essential for long-term health [14].
NAD+ boosters and resveratrol should be viewed as supportive tools, not replacements for healthy habits.
For most healthy adults, early studies suggest NAD+ boosters and resveratrol are generally safe [13].
However, anyone who is pregnant, breastfeeding, or taking prescription medication should check with a healthcare professional before starting.
Who is Taking NAD+ and Resveratrol?
It is not only scientists who are interested in NAD+ and resveratrol. Several well-known figures in the longevity and biohacking community have spoken publicly about using them in their routines.
- Gary Brecka: A human biologist and wellness entrepreneur, Brecka often discusses NAD+ precursors such as NMN in podcasts and interviews. He highlights their role in supporting energy and overall vitality [15].
- Dr Peter Attia: A physician focused on longevity, Attia frequently explores NAD+ metabolism and resveratrol in his books, podcasts, and blog. He discusses them as part of broader strategies for healthy ageing [16].
- Bryan Johnson: The entrepreneur behind the “Blueprint” protocol has shared details of his supplement stack, which includes NAD+ boosters and resveratrol, as part of his highly structured anti-ageing plan [17].
These examples do not prove clinical benefits but show how the combination has gained popularity among high-profile voices in the field of longevity.
Conclusion
NAD+ boosters and resveratrol are two of the most talked-about supplements in the longevity space.
On their own, they may play important roles in energy production, DNA repair, and cellular protection. Together, they may work in synergy to support healthy ageing by fuelling and activating the pathways linked with resilience over time.
While much of the research is still in its early stages, interest from scientists and wellness experts continues to grow. For people who are health-conscious and curious about longevity, combining NAD+ boosters such as NMN or NR with resveratrol may be a practical way to support their wellness routine.
As always, supplements should be viewed as part of a balanced lifestyle that includes sleep, nutrition, and movement. By staying informed and making thoughtful choices, you can take steps to invest in your long-term health.
Reviewed by Paul Holmes
Director of Science and Innovation at Naturecan
Testing for large pharmaceutical & tobacco companies, Paul has built a wealth of scientific and regulatory knowledge, working on regulatory submissions to bodies such as the FDA and the MHRA.
He holds a BSc in Medicinal and Biological Chemistry and sits on the UKAS CBD Food Product Approval Expert Group.
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