Top 6 Potential NMN Benefits

Woman in orange gym set holding supplements and glass of water

Written by Jordan Caulfield & Reviewed by Paul Holmes.

    Nicotinamide Mononucleotide (NMN) has gained increasing attention in recent years in the health and wellness industry.

    This is due to its impressive potential benefits in promoting longevity and overall well-being. As a precursor to NAD+, NMN plays a crucial role in cellular energy production, DNA repair, and metabolic function. However, as we age, NMN levels decline, making it harder for the body to maintain optimal NAD+ levels.

    This article explores the emerging benefits of NMN, exactly how it works in the body, the best dietary sources, potential side effects, and the advantages of supplementation.

    We will also cover how NMN may contribute to longevity and which supplements may enhance its effects for a more comprehensive approach to day-to-day health.

    What Is NMN?

    Nicotinamide mononucleotide (NMN) is a naturally occurring compound in the human body and certain foods. It plays an important role in cellular metabolism and is a precursor to nicotinamide adenine dinucleotide (NAD+), a vital molecule that facilitates many biological processes.

    As we age, NMN levels decline, making it more challenging for the body to maintain high NAD+ levels for energy production and overall cellular health. NMN supplementation may help mitigate age-associated physiological decline by restoring NAD+ levels and improving overall health and vitality.

    How Does NMN Work?

    NMN works by converting into NAD+, a coenzyme that fuels various important bodily functions. The body relies on NAD+ to sustain mitochondria, the powerhouse of cells, ensuring efficient energy production and overall vitality.

    So, as NAD+ levels drop with age, increasing your NMN intake through supplementation or diet can help replenish these levels, potentially mitigating age-related decline and enhancing cellular function.

    digest gummies naturecan
    Digest Gummies Benefits. Proven Probiotics
    Probiotiikum Digest Supplement
    digest gummies naturecan
    Digest Gummies Benefits. Proven Probiotics
    Probiotiikum Digest Supplement

    Digest Gummies

    £22.39
    Apple Cider Vinegar Gummies
    Apple Cider Vinegar Gummies
    Apple Cider Vinegar Gummies
    Apple Cider Vinegar Gummies
    Apple Cider Vinegar Gummies
    Apple Cider Vinegar Gummies
    Apple Cider Vinegar Gummies
    Apple Cider Vinegar Gummies
    Apple Cider Vinegar Gummies
    Apple Cider Vinegar Gummies

    Apple Cider Vinegar Gummies

    £22.49
    Healthy-Ageing Longevity Bundle
    Healthy-Ageing Longevity Bundle

    Healthy-Ageing Longevity Bundle

    £99.39
    NMN supplement
    NMN Supplement
    NMN supplement uk
    nmn benefits
    NMN supplement
    NMN Supplement
    NMN supplement uk
    nmn benefits

    NMN Supplement

    £29.99

    NMN & NAD+ - How They Work Together

    As previously discussed, NAD+ is an essential molecule for healthy bodily function as well as various biochemical processes like metabolism and DNA repair.

    NAD+ levels influence gene expression related to metabolism and ageing, and NMN helps restore these levels.When these levels decrease over time, this opens up vulnerability in the body, leading to decreased cellular function and potential age-related diseases.

    NMN serves as a direct precursor to NAD+, helping to restore its levels efficiently.

    Decline of NAD+ Levels with age line graph

    What Are The Benefits Of NMN?

    There are a variety of potential benefits of NMN, including:

    • Enhanced Energy Metabolism: NMN boosts NAD+ levels, which support mitochondrial function, leading to increased energy production. [1]
    • Improved Cognitive Function: Research suggests that NMN may enhance brain function and reduce age-related cognitive decline.
    • Support for Cardiovascular Health: Studies indicate that NMN may contribute to improved blood flow and heart health. [3]
    • DNA Repair and Longevity: NMN supports the activation of sirtuins, proteins involved in DNA repair and longevity. [4]
    • Mitigation of Age-Associated Weight Gain: NMN could help mitigate age-associated weight gain by enhancing energy metabolism and improving insulin sensitivity. [5]
    • Safety in Clinical Trials: Clinical trials have shown NMN does not adversely affect blood pressure, supporting its safety for consumption. [6]
    brain health image made out of paper with jigsaw pieces

    NMN Benefits for Energy Metabolism and Insulin Sensitivity

    Boosts Energy Metabolism

    NMN can potentially enhance energy metabolism by increasing NAD+ levels in the body.

    NAD+ is a coenzyme that is essential for energy production. As NAD+ levels dip with age, supplementation of NMN can boost NAD+ levels, to support improved energy metabolism, and potentially reduce fatigue.

    This makes NMN a growing supplement, popular for its potential in supporting overall longevity and vitality.

    man in blue gym top and woman in all black running

    Improves Insulin Sensitivity

    Insulin sensitivity is responsible for maintaining healthy blood sugar levels, and like most things in the body, it tends to decline with age, which can increase the risk of type 2 diabetes.

    A recent study showed that NMN was observed to potentially enhance hepatic insulin sensitivity and restore the expression levels of genes involved in oxidative stress. [7]

    By enhancing insulin sensitivity, NMN may help maintain healthy blood sugar levels and support overall metabolic health.

    Person checking blood sugar levels with machine

    Enhances Immune System Function

    Supporting the immune system, particularly as we age, is vital. With a low immune system, you become vulnerable to illnesses that would not normally be life-threatening, but with a weakened immune system, the body has to work much harder to fight them off.

    NMN may play a vital role in enhancing immune system function. As NAD+ is critical for the proper functioning of immune cells, a decreased level in NAD+ can lead to a weakened immune response.

    Increasing NMN intake can help boost NAD+ levels, thereby supporting healthy immune system function and providing potential better protection against infections and diseases. By enhancing a robust immune system, NMN may support longevity and overall well-being.

    woman sat in bed blowing nose in pyjamas

    Foods That Contain NMN

    NMN can be incorporated into the diet as it's also naturally present in various foods, but its levels are relatively low.

    For example, one of the highest NMN-rich foods would be avocados, but these contain on average 0.36 to 1.60 milligrams (mg) of nicotinamide mononucleotide (NMN) per 100 grams. Whereas supplements contain 500mg of NMN per serving.

    But despite this, it is still important to include NMN-rich foods in your diet as natural sources and as part of a balanced diet.

    Some NMN-rich foods include:

    • Broccoli
    • Avocados
    • Cabbage
    • Cucumbers
    • Edamame
    • Tomatoes
    • Mushrooms

    Incorporating these foods into your diet can provide a natural source of NMN as part of your day-to-day. Although, supplementation may be necessary to achieve effective levels of NMN in the body.

    NMN (10).webp__PID:39f65e00-3e3d-4803-a7ff-770e4570c310

    Are There Any Side Effects Of NMN?

    NMN is generally considered safe with minimal side effects.

    However, as with anything, some individuals may experience mild symptoms such as:

    • Nausea
    • Digestive discomfort
    • Fluctuations in energy levels
    • Insomnia (if taken too late in the day)

    It's always advisable to consult a healthcare professional before starting NMN supplementation.

    NMN Supplements: How Can They Help?

    NMN supplements provide a convenient way to increase NAD+ levels efficiently. They are easily incorporated into a daily wellness regime in capsule form, taking just one a day to receive your daily needed intake of NMN.

    Naturecan’s NMN supplement is an easily incorporated, premium supplement designed to help maintain optimal NAD+ levels and enjoy the associated benefits.

    Supplements To Take Alongside NMN

    Certain supplements can enhance NMN’s effects when taken together. Some of the most beneficial include:

    • Curcumin: Supports anti-inflammatory processes.
    • Resveratrol: Works synergistically with NMN to activate sirtuins.
    • Spermidine: Promotes autophagy and cellular rejuvenation.
    • Quercetin: Enhances NAD+ metabolism

    Additionally, the Naturecan NMN & Resveratrol bundle offers a combined approach to supporting overall well-being. Containing a 2 month supply of both NMN and Resveratrol, it is the perfect supplementation duo for longevity support.

    NMN And Longevity - Do They Go Hand In Hand With Anti Ageing?

    Research suggests that NMN supplementation could support anti-aging by maintaining NAD+ levels.

    NAD+ plays a critical role in DNA repair, energy production, and cellular health, all of which contribute to a longer, healthier life. The various health benefits of NMN supplementation include its potential to enhance health span and lifespan by addressing age-related decline and metabolic disorders.

    While more human studies are needed, current research indicates promising potential for NMN in promoting longevity. Research shows that NMN may slow down processes such as oxidative stress and cognitive impairment [8] which are both key catalysts in the ageing process.

    Read more on what is longevity

    FAQs About NMN

    Where can you get NMN?
    NMN is found in various foods and also as through NMN supplements.

    Is NMN legal?
    Yes, NMN is legal in many countries, though regulations may vary from region to region.

    What happens if you stop taking NMN?
    Stopping NMN supplementation can lead to a gradual decline in NAD+ levels, potentially reducing its benefits.

    How long do the effects of NMN last?
    The effects of NMN can last several hours, depending on metabolism and dosage

    When to take NMN?
    It’s best to take NMN in the morning to avoid potential sleep disturbances.

    Conclusion

    NMN supplementation presents a promising approach to supporting cellular health, energy production, and overall longevity.

    By incorporating NMN into your daily routine, particularly alongside complementary supplements like resveratrol and curcumin, you can enhance your wellness journey.

    Brain health graphic made with clay

    Brain Health and Longevity: How to Protect Your Brain as You Age

    Let’s explore the profound link between cognitive resilience and extended lifespan.

    Read Article
    trending gummies.webp__PID:eab5a468-41e3-4feb-9aa7-4a6d11df9287

    Top Trending Gummies Of 2025: A Comprehensive Guide

    This article explores the most trending gummies in 2025 and highlights how Naturecan offers premium-quality options in these categories.

    Read Article
    Older woman sat in vest

    8 ways: how to boost your immune system

    This guide explores the key causes of ageing, the potential health benefits of longevity supplements, and how to integrate them into a lifestyle that promotes healthy ageing.

    Read Article
    References

    1. Harshani Nadeeshani, Jinyao Li, Tianlei Ying, Baohong Zhang, Jun Lu. Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns.

    2. Tarantini S, Valcarcel-Ares MN, Toth P, Yabluchanskiy A, Tucsek Z, Kiss T, Hertelendy P, Kinter M, Ballabh P, Süle Z, Farkas E, Baur JA, Sinclair DA, Csiszar A, Ungvari Z. Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice.

    3. Zhang X, Zhang Y, Sun A, Ge J. The effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential.

    4. Liao, G., Xie, Y., Peng, H. et al. Advancements in NMN biotherapy and research updates in the field of digestive system diseases. J Transl Med 22, 805 (2024)

    5. Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice.

    6. Song Q, Zhou X, Xu K, Liu S, Zhu X, Yang J. The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update.

    7. Liao, G., Xie, Y., Peng, H. et al. Advancements in NMN biotherapy and research updates in the field of digestive system diseases. J Transl Med 22, 805 (2024).

    8. Harshani Nadeeshani, Jinyao Li, Tianlei Ying, Baohong Zhang, Jun Lu : Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns, Journal of Advanced Research,Volume 37, 2022.