12 Causes of Ageing: How to Combat it with Anti-Ageing Supplements

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Written by Georgia Chappell and reviewed by Paul Holmes

Ageing is a natural, unavoidable process, but its visible and internal effects differ greatly depending on genetics, lifestyle, and environmental factors.

While the passage of time cannot be halted, science offers tools and strategies to address the causes of ageing.

One such avenue is the growing use of anti-ageing supplements, which target specific ageing mechanisms and may support longevity, skin moisture, vitality, and overall health.

These supplements aim to combat cellular decline, oxidative stress, and hormonal imbalances—factors that contribute to wrinkles, fatigue, and age-related diseases and health concerns.

This guide explores the key causes of ageing, the potential health benefits of longevity supplements, and how to integrate them into a lifestyle that promotes healthy ageing.

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Why Do We Age?

The Natural Ageing Process

Ageing occurs due to a combination of biological processes and environmental influences.

Over time, cellular mechanisms slow down, DNA accumulates damage, and the body becomes less efficient at repairing itself.

Common elements of the natural ageing process include:

  • Loss of collagen and elastin: These proteins maintain skin health, elasticity and firmness but naturally decline with age.
  • Mitochondrial dysfunction: The cellular powerhouses that generate energy lose efficiency, leading to reduced vitality.
  • DNA damage: Exposure to toxins, UV light, and oxidative stress accelerates damage to the body’s genetic material.

This gradual decline affects not only appearance but also energy levels, joint health, and cognitive function. However, certain lifestyle changes and targeted supplements may slow or counteract these effects.

Why do we age?

The Role of Genetics and Environment

Genetics play a significant role in determining how quickly and visibly a person ages. Factors such as collagen production, hormonal balance, and cellular repair efficiency are influenced by inherited traits. However, environmental factors such as pollution, stress, and diet also significantly impact ageing.

For instance:

  • Stress triggers hormonal imbalances, leading to inflammation and skin ageing.
  • Pollution introduces free radicals, which damage cells and reduce skin elasticity.
  • Diet lacking in essential nutrients can exacerbate collagen loss and slow cellular repair.

By combining healthy lifestyle practices with anti-ageing supplements, it is possible to mitigate these influences and maintain vitality for longer.

Discover 10 Potential Benefits of Collagen

12 Key Causes of Ageing

Anti-Aging FactorSuggested Supplement Key BenefitsShop Now
Oxidative StressVitamin CNeutralizes free radicals, boosts collagen synthesis, enhances cellular repairVitamin C Capsules
Loss of Collagen and ElastinCollagen PeptidesReplenishes collagen, improves skin texture and hydration, supports joint healthCollagen Peptides
Mitochondrial DeclineNMNBoosts cellular energy, supports longevity, and enhances cognitive functionNMN Supplements
Hormonal ChangesAshwagandhaRegulates stress hormones, supports hormonal balance, and boosts energy and resilienceKSM-66® Ashwagandha
Genomic InstabilityResveratrolPromotes DNA repair, activates longevity pathways, and combats oxidative stressResveratrol Supplements
Epigenetic AlterationsCurcuminSupports healthy gene expression, potentially reduces inflammation, and enhances cognitive resilienceActive Curcumin
Telomere ShorteningAstragalusMay preserve telomere length, enhance immune health, and improve tissue repairAstragalus Supplements
Cellular SenescenceQuercetinClears harmful senescent cells, possibly reduces inflammation, and improves skin qualityQuercetin Supplements
Proteostasis DeclineBCAAsSupports muscle repair, maintains protein health, and reduces cellular stressBCAA Supplements
Gut Microbiome ImbalanceDigest CapsulesRestores gut health, boosts immunity, and improves nutrient absorptionDigest Capsules
Cross-Linking of ProteinsAlpha-Lipoic AcidCombats glycation effects, improves skin elasticity, and neutralizes free radicalsAlpha-Lipoic Acid Supplements

1. Oxidative Stress

Oxidative stress occurs when there is an imbalance between free radicals—unstable molecules that damage cells—and antioxidants, which neutralize them, leading to age-related diseases. This imbalance accelerates the ageing process by breaking down collagen, damaging DNA, and impairing cellular repair.

How it affects ageing:

  • Skin damage: Leads to fine lines, wrinkles, and uneven pigmentation.
  • Cellular dysfunction: Damaged cells have reduced capacity for energy production and repair.

How to combat it naturally:

Incorporate antioxidant-rich foods like blueberries, spinach, and dark chocolate into your diet.

Suggested Supplement: Vitamin C

  • Protects skin health from damage: Vitamin C neutralizes free radicals, preventing oxidative damage to collagen and other skin structures.
  • Boosts collagen synthesis: This essential nutrient helps rebuild skin’s elasticity, reducing wrinkles over time.
  • Supports overall resilience: Its antioxidant properties enhance cellular repair, supporting long-term vitality.
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2. Chronic Inflammation

Inflammation is the body’s response to injury or infection, but chronic inflammation accelerates ageing by damaging tissues, breaking down collagen, and increasing oxidative stress.

How it affects ageing:

  • Skin health: Chronic inflammation weakens the skin barrier, causing redness, sensitivity, and premature wrinkles.
  • Joint and organ health: Persistent inflammation contributes to joint stiffness, pain, and reduced organ function.

How to combat it naturally:

Adopt an anti-inflammatory diet rich in omega-3 fatty acids, turmeric, and leafy greens.

3. Loss of Collagen and Elastin

Collagen and elastin provide the structural framework for firm, youthful skin. As their production decreases with age, the skin becomes thinner, drier, and more prone to sagging and wrinkles.

How it affects ageing:

  • Wrinkles and fine lines: Reduced collagen and elastin leave skin unable to retain its shape.
  • Dryness and dullness: Loss of these proteins impacts hydration and radiance.

How to combat it naturally:

Eat protein-rich foods like chicken, fish, and eggs, along with vitamin C-rich produce such as citrus fruits and bell peppers.

Suggested Supplement: Collagen Peptides

  • Restores elasticity: Collagen peptide supplementation replenishes the body’s natural stores, improving skin texture and reducing wrinkles.
  • Boosts hydration: Collagen helps retain moisture, leading to smoother, plumper skin.
  • Promotes joint health: It supports cartilage, reducing stiffness and enhancing mobility.
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4. Mitochondrial Decline

Mitochondria are the energy powerhouses of cells, converting nutrients into energy. As they become less efficient with age, cells struggle to perform vital functions, resulting in fatigue and slower metabolism. 

How it affects ageing:

  • Energy levels: Decreased mitochondrial function leads to chronic tiredness and reduced physical stamina.
  • Metabolic health: A slower metabolism impacts weight management and cellular repair.

Suggested Supplement: NMN (Nicotinamide Mononucleotide)

  • Increases cellular energy: NMN supplements boost levels of NAD+, a molecule critical for mitochondrial function, improving energy and endurance.
  • Supports longevity: By enhancing mitochondrial health, NMN may slow cellular ageing and promote longevity.
  • Improves cognitive function: Increased energy supports brain health, reducing mental fatigue.
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5. Hormonal Changes

Hormonal shifts, such as those during menopause or andropause, significantly impact ageing. These changes affect skin elasticity, bone density, and mood regulation.

How it affects ageing:

  • Skin dryness: Reduced estrogen leads to less hydrated, more fragile skin.
  • Mood and energy: Hormonal imbalances can cause fatigue, irritability, and depression.

How to combat it naturally:

Practice stress management techniques like yoga or mindfulness to balance cortisol levels.

Suggested Supplement: Ashwagandha

  • Regulates stress hormones: Ashwagandha helps lower cortisol levels, potentially reducing stress-related ageing.
  • Supports hormonal balance: It may alleviate symptoms of menopause and enhance mood.
  • Boosts energy and resilience: This adaptogen promotes overall vitality, helping the body cope with stressors.
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6. Genomic Instability

Over time, DNA accumulates damage from environmental toxins, UV radiation, and oxidative stress. This genomic instability disrupts cellular function, increasing the risk of age-related diseases.

How it affects ageing:

  • Tissue degeneration: Damaged DNA leads to reduced cell renewal and repair.
  • Disease susceptibility: Genomic instability is linked to conditions such as cardiovascular disease.

Suggested Supplement: Resveratrol

  • Protects DNA: Resveratrol promotes DNA repair and reduces the accumulation of mutations.
  • Activates longevity pathways: It stimulates sirtuins, proteins that regulate cellular ageing.
  • Combats oxidative stress: Its antioxidant properties support overall cellular health.
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7. Epigenetic Alterations

Epigenetics refers to changes in gene expression caused by environmental and lifestyle factors. These changes can disrupt cellular processes, accelerating visible signs of ageing.

How it affects ageing:

  • Premature skin ageing: Epigenetic changes may impair protein production, reducing skin elasticity.
  • Reduced cellular efficiency: Altered gene expression impacts energy production and repair mechanisms.

Suggested Supplement: Curcumin

  • Supports healthy gene expression: Curcumin helps regulate epigenetic changes, promoting optimal cellular function.
  • Reduces inflammation: Its potential anti-inflammatory effects protect against skin ageing and cellular damage.
  • Boosts brain health: Curcumin enhances cognitive resilience, reducing age-related mental decline.
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8. Telomere Shortening

Telomeres are protective caps at the ends of chromosomes, preventing genetic material from deteriorating. As we age, telomeres shorten, leading to cellular dysfunction and eventual cell death.

How it affects ageing:

  • Slower cell renewal: Shortened telomeres reduce the body’s ability to repair tissues.
  • Increased susceptibility to disease: Cellular decline contributes to age-related conditions.

Suggested Supplement: Astragalus

  • Preserves telomere length: Astragalus contains compounds that may protect and extend telomeres.
  • Enhances immune health: It boosts the body’s ability to fight infections and stress.

9. Cellular Senescence

Senescent cells, often called “zombie cells,” stop dividing but remain metabolically active, releasing harmful compounds that damage surrounding tissues.

How it affects ageing:

  • Chronic inflammation: Senescent cells contribute to tissue degradation and immune dysfunction.
  • Reduced cellular efficiency: Altered gene expression impacts energy production and repair mechanisms.

Suggested Supplement: Quercetin

  • Eliminates senescent cells: Quercetin acts as a senolytic, helping clear these harmful cells from the body.
  • Improves skin quality: It supports healthy skin by possibly reducing inflammation and oxidative stress.

10. Proteostasis Decline

Proteostasis refers to the body’s ability to maintain healthy proteins. As we age, protein misfolding increases, leading to cellular dysfunction and neurodegenerative diseases.

Suggested Supplement: BCAAs (Branched-Chain Amino Acids)

  • Supports muscle repair: BCAAs aid protein synthesis, maintaining muscle health and reducing sarcopenia (age-related muscle loss).
  • Improves cellular stability: They help ensure proper protein folding, reducing cellular stress.

11. Gut Microbiome Imbalance

A disrupted gut microbiome impacts digestion, immunity, and systemic inflammation, accelerating ageing.

Suggested Supplement: Digest Capsules

  • Restores gut health: Digest capsules replenish beneficial bacteria, improving nutrient absorption.
  • Boosts immunity: A balanced microbiome strengthens overall health and resilience.
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12. Cross-Linking of Proteins

Protein cross-linking occurs when sugar molecules bind to proteins, reducing tissue elasticity. This process affects skin firmness and joint flexibility.

Suggested Supplement: Alpha-Lipoic Acid

  • Reduces glycation effects: Alpha-lipoic acid combats protein cross-linking, improving skin elasticity.
  • Supports antioxidant defenses: It neutralizes free radicals, protecting tissues from damage.

How to Choose the Best Anti-Ageing Supplements

When selecting anti-ageing supplements, consider these factors:

  • Ingredient quality: Look for clinically tested, high-purity ingredients.
  • Third-party testing: Ensure the product is verified for safety and efficacy.
  • Specific goals: Choose supplements tailored to your needs, such as collagen for skin health or NMN for energy.
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Conclusion

Ageing is a complex process, but understanding its causes allows for targeted interventions.

By integrating anti-ageing supplements with healthy lifestyle practices, it is possible to maintain vitality, support longevity, and age gracefully.Always consult a healthcare professional to tailor your supplement routine to your specific needs.

FAQs About Anti-Ageing Supplements

Do Anti-Ageing Supplements Work?
Yes, when combined with a healthy lifestyle, supplements can target specific ageing mechanisms, such as oxidative stress and collagen decline, to promote vitality.

Which Anti-Ageing Supplement is the Best? 
The best supplement depends on individual needs. Collagen is ideal for skin health, while NMN and Resveratrol support energy and cellular longevity.

How to Slow Down Ageing?
Adopt a balanced lifestyle with nutrient-rich foods, regular exercise, stress management, and targeted supplementation to support cellular health.

How to Shift an Ageing Mind into Reverse?
Cognitive decline can be addressed with brain health supplements like curcumin and mindfulness practices to enhance mental resilience.

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