10 Best Longevity Supplements

1. Resveratrol

Resveratrol is a potent polyphenol and antioxidant found naturally in the skin of red grapes, certain berries, peanuts, and dark chocolate.

It has gained significant attention for its potential health benefits, particularly in the context of ageing and longevity. Pterostilbene is also a known part of Resveratrol, which we will discuss more later on in this article. This compound is also famously present in red wine, leading to widespread interest in its effects on health and lifespan.

Potential Benefits of Resveratrol

• Heart Health: Resveratrol is believed to support cardiovascular health, as a 2020 study found that through various mechanisms, including improving endothelial function, reducing inflammation, and offering protection against the oxidation of LDL cholesterol, which is a crucial factor in the development of atherosclerosis.
• Ageing and Longevity: Studies suggest that resveratrol can activate specific genes associated with longer lifespans and mimic the effects of caloric restriction, a known factor in extending lifespan in various organisms. Furthermore, findings conclude that It may influence mechanisms involved in ageing, such as DNA repair, the production of protective enzymes, and the reduction of inflammatory processes.
• Metabolic Benefits: There is evidence to suggest that resveratrol can improve insulin sensitivity and help manage blood glucose levels, according to a 2018 study, making it a compound of interest in the context of metabolic syndrome and diabetes prevention.
• Neuroprotection: Preliminary research indicates that resveratrol may have protective effects on brain health, potentially reducing the risk of neurodegenerative diseases like Alzheimer's by inhibiting the buildup of plaques and oxidative stress in the brain.

Featured Supplement:
Resveratrol

Discover our new high purity Resveratrol & Rosemary supplement! Brand new to our Naturecan range, our Resveratrol supplements are designed to support your cardiovascular health and overall well-being.

Hence, incorporating our pure Resveratrol capsules into your daily regimen is an excellent choice for anyone looking to enhance their wellness journey.

Potential Benefits:

• 500mg of Resveratrol per capsule
• Premium capsule technology
• May improve cardiovascular health
• Two-month supply of capsules
• Made in Europe
• Suitable for vegans

2. NAD+ Boosters (NMN: Nicotinamide mononucleotide)

Nicotinamide Mononucleotide (NMN) is a critical precursor to Nicotinamide Adenine Dinucleotide (NAD+), a coenzyme essential for a wide array of biological processes. NAD+ plays a pivotal role in energy metabolism, DNA repair, and the regulation of cellular and ageing processes, making NMN supplementation a promising avenue for enhancing longevity and healthspan.

Sources of NMN

 NMN is present in small quantities in foods such as avocados, broccoli, cabbage, cucumbers, and edamame. However, these amounts are not sufficient to impact the levels of NAD+ in other nutrients in the body. This led to NMN supplements being created to increase NAD+ levels in other nutrients more effectively than diet alone.

How Much to Take Daily

The optimal dosage of NMN is still under investigation, with human studies still exploring a wide range of doses. Most human studies have used doses ranging from 250 mg to 1,000 mg per day, showing promising results in terms of safety and efficacy. However, individual needs may vary, and it's advisable to consult with a healthcare provider to determine the appropriate dosage.

Featured Supplement:
NMN

We are excited to announce the addition of our high purity NMN Supplement (nicotinamide mononucleotide) to our Naturecan range! Designed to support overall health and well-being, incorporating our pure NMN supplement into your daily regimen is an excellent choice for anyone looking to enhance their wellness and longevity journey.

Potential Benefits:

• 500mg of NMN (Nicotinamide mononucleotide) per capsule
• Premium capsule technology 
• May increase lifespan
• NAD+ Booster

3. Spermidine: A Key to Cellular Renewal and Longevity

Spermidine is a naturally occurring compound found both in the body and various foods. It plays a crucial role in autophagy, the body's cell renewal and cleaning process, which is linked to increased lifespan.

• Sources: You can find spermidine in foods like wheat germ, aged cheese, mushrooms, and soy products. It's also available as a dietary supplement for those looking to boost their intake.
• Benefits: By promoting autophagy, spermidine helps in the maintenance of cellular health, potentially extending longevity and enhancing overall well-being.
• Dosage: While there's no established guideline for supplement dosage, incorporating spermidine-rich foods into your diet is a safe way to enjoy its benefits.

Featured Supplement: Spermidine

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Spermidine is a naturally occurring compound found in foods like wheat germ, soy, and mushrooms. It plays a role in autophagy, the body’s process of cellular renewal, helping to clear out damaged cells and support overall cellular health.

Potential Benefits:

• 60 Servings of premium Spermidine Capsules
• 5mg Spermidine per serving
• Scientifically supportive ingredients
• Vegan

4. Pterostilbene: Nature's Antioxidant Powerhouse

Pterostilbene, a natural compound akin to resveratrol, is celebrated for its potent antioxidant effects. Found in the heart of blueberries and grapes, this compound offers a myriad of health benefits.

• Sources: Richly present in blueberries and grapes, pterostilbene is also available as a dietary supplement, making it easy to incorporate into your daily routine.
• Health Benefits: According to recent studies, pterostilbene shines in its ability to bolster heart health and cognitive function while playing a significant role in anti-ageing efforts. Its antioxidant properties help combat oxidative stress, contributing to overall well-being.
• Recommended Dosage: For those considering supplementation, initial studies recommend a daily intake of 50-250 mg. This range is suggested to harness pterostilbene's full potential while ensuring safety and efficacy.

6. Rosmarinus (Rosmarinic acid)

Rosmarinus officinalis, commonly known as rosemary, is a herb known for its aromatic and therapeutic properties. One of its active compounds, rosmarinic acid, has been studied for various health benefits, including its potential impact on longevity and healthspan. Here's how rosmarinic acid might influence these areas:

• Antioxidant Properties: According to studies, rosmarinic acid is a potent antioxidant that helps neutralise harmful free radicals in the body. By reducing oxidative stress, it may help protect cells from damage that contributes to ageing and the development of chronic diseases.
• Anti-inflammatory Effects: A 2022 review found that chronic inflammation is associated with many age-related diseases. Rosmarinic acid has been shown to have anti-inflammatory properties, which could potentially reduce the risk of conditions like heart disease, diabetes, and Alzheimer's, thereby potentially contributing to a longer healthspan.
• Neuroprotective Effects: There is evidence to suggest that rosmarinic acid has neuroprotective effects, which could play a role in preventing or slowing the progression of neurodegenerative diseases such as Alzheimer's and Parkinson's. This could contribute to maintaining cognitive function and quality of life in older age.
• Supporting Metabolic Health: Some studies suggest that rosmarinic acid may have beneficial effects on metabolic health, including improving insulin sensitivity and reducing the risk of obesity and type 2 diabetes. Metabolic health is crucial for longevity and a healthy ageing process.

7. Sirtuin 6 (SIRT6): Enhancing Cellular Health

SIRT6 belongs to the sirtuin family, proteins crucial for DNA repair, metabolism regulation, and ageing. It deacetylates proteins, an essential process for cellular health and longevity.

Sources:

Endogenously produced, SIRT6 activity can be boosted by lifestyle choices. Caloric restriction, physical exercise, and a diet rich in polyphenols (from berries, nuts, and red wine) enhance its function.

Potential Benefits:

• Longevity: This plays a vital role in DNA repair and telomere maintenance, contributing to cell longevity.
• Metabolic Health: Helps regulate glucose and lipid metabolism, aiding in metabolic disease prevention.
• Inflammation Reduction: Involved in suppressing inflammatory responses, potentially reducing related diseases.

Dosage: Direct SIRT6 dosage isn't applicable, as it's a gene-encoded protein. Its activity is enhanced through healthy lifestyle practices. Research into activating compounds, including polyphenols and NAD+ precursors like nicotinamide riboside (NR), is ongoing. SIRT6 is crucial for maintaining cellular health, with benefits for longevity, metabolic health, and inflammation control. While not directly supplementable, lifestyle and dietary choices significantly influence its activity, promoting better health outcomes.

Featured Supplement: NAD

Nicotinamide Riboside (NR) is a special type of vitamin B3 that helps increase NAD+ levels in our cells. NAD+ is a molecule our bodies need for energy and to keep our cells healthy, but it naturally decreases as we age, which can lead to feeling tired and impacts our cells' health.

Potential Benefits:

• 90 Servings of premium Nicotinamide Riboside (NR, 90 day supply)
• 300 mg NR per serving (1 capsule per day)
• Vegan

8. Metformin

Metformin is a prescription medication primarily used to treat type 2 diabetes. It belongs to a class of drugs known as biguanides and works by decreasing glucose production in the liver, improving the body's sensitivity to insulin, and reducing the amount of sugar absorbed by the intestines.

One notable study is the ongoing TAME (Targeting ageing with Metformin) trial, which aims to assess Metformin's ability to delay the onset of age-related diseases and conditions, effectively targeting the ageing process itself rather than anti-aging rather than individual diseases. This study and others like it seek to provide more concrete evidence on Metformin's potential to enhance healthspan and possibly lifespan in humans.

While the research is promising, it's important to note that the use of Metformin specifically for longevity is still under investigation, and more data are needed to fully understand its effects and implications in this context.

Sources: Metformin is not found in natural sources and is available only through prescription. It comes in several forms, including tablets, an extended-release (long-acting) tablet, and a liquid. Metformin is often sold under brand names like Glucophage, Glumetza, and Fortamet, among others.

9. Rapamycin: A Comprehensive Overview with a Focus on NMN Synergy

Both rapamycin and NMN have been spotlighted in longevity studies, albeit through distinct mechanisms. NMN, a precursor to NAD+ (Nicotinamide Adenine Dinucleotide), is pivotal in enhancing cellular energy metabolism and repairing DNA. When considered alongside rapamycin's mTOR inhibition, these compounds collectively offer a multifaceted approach to slowing the ageing process, improving metabolic health, and enhancing longevity.

Key Benefits:

• Immunosuppression: Rapamycin is effectively used to prevent organ transplant rejection by dampening the immune response.
• Anti-ageing and Longevity: It has shown promise in extending lifespan in animal models by mimicking the effects of caloric restriction.
• Neuroprotection: Early research suggests potential benefits against neurodegenerative diseases through autophagy promotion.
• Synergistic Effects with NMN: The combination of rapamycin and NMN is being explored for their complementary roles in supporting healthspan and combating age-related decline.

10. Fisetin

Fisetin has attracted attention in longevity research for its ability to influence senescence, a state of cellular ageing where cells no longer divide. By reducing the burden of senescent cells, fisetin may help alleviate age-related tissue dysfunction and promote healthier ageing.

This effect, combined with its antioxidant properties, positions fisetin as a promising compound in the quest to extend healthspan and potentially lifespan.

Key Benefits:

• Senolytic Activity: Fisetin is recognised for its ability to selectively induce the death of senescent cells, thereby improving overall cellular function and reducing age-related tissue degeneration.
• Antioxidant and Anti-inflammatory Effects: It combats oxidative stress and inflammation, two key drivers of ageing and chronic diseases.
• Neuroprotection: There is emerging evidence that fisetin may offer protective effects against neurodegenerative diseases, possibly through its antioxidant actions and ability to enhance brain function.

Featured Supplement: Fisetin

Discover the potential of our Fisetin Supplement, an all-natural plant compound taking the wellness industry by storm, due to its role in potentially supporting healthy ageing, cellular function, and overall well-being.

Potential Benefits:

• Supports healthy cellular function
• Made in Europe in a GMP-Facility
• May contribute to healthy ageing
• May support the body's natural inflammatory response

Featured Supplement: Collagen Peptides

Enhance your well-being with our advanced collagen peptides supplement! Designed to support your body during times of stress and increased nutritional demands, this innovative formula features three powerful ingredients, supported by 15 clinical studies—providing far more than your standard collagen supplement.

Potential Benefits:

• 300g, 600g or 900g of premium collagen peptides, containing 12.5g of collagen per serving
• Scientifically supported ingredients
• Also contains Zinc and Copper
• Vitamin C supports normal collagen function of skin (1), bones (7) and joint cartilage (8)

How to Choose and Use Longevity Supplements

• Consult Healthcare Providers: Always discuss with a healthcare professional before starting any supplement regimen.
• Quality Matters: Opt for supplements from reputable manufacturers with transparent ingredient sourcing.
• Lifestyle Integration: Supplements should complement a healthy diet, regular exercise, and adequate sleep.
• Lifestyle Integration: Supplements should complement a healthy diet, regular exercise, and adequate sleep.

The Science Behind Longevity

At its core, the science of longevity seeks to understand the biological mechanisms that contribute to ageing and how to mitigate these factors to enhance both lifespan and health span. Research in this field explores ageing processes in various aspects, including genetics, cellular senescence, telomere length, and the impact of lifestyle factors like diet, exercise, and stress management.

The Role of Lifestyle and Genetics

Longevity is influenced by a combination of genetics and lifestyle choices. While genetic factors can predispose individuals to longer lives, lifestyle choices are crucial. Healthy diets, regular physical activity, stress reduction, and avoidance of harmful habits like smoking and excessive alcohol consumption can significantly contribute to extending one's lifespan and improving overall health quality.

The Impact of Modern Medicine and Technology

Advancements in medical science and technology have also played a pivotal role in reducing mortality and extending average life expectancies. Innovations in healthcare, from vaccines and antibiotics to modern surgical techniques and chronic disease management, have drastically reduced mortality rates from infectious diseases and improved outcomes for various health conditions.

Longevity and Quality of Life

Ultimately, the pursuit of healthy longevity supports healthy ageing, and is not just about adding more years to life but adding more life to those years. It involves enhancing the quality of life, maintaining physical and mental health, and ensuring that individuals can live independently and with dignity as they age.

What Are Telomeres and Why Do They Matter?

Telomeres are the protective caps at the ends of our chromosomes, essential for maintaining genetic stability. Over time, telomeres shorten, a process linked to ageing and disease. Understanding telomeres offers insights into how longevity supplements might contribute to a healthier, extended life.

Why the Trend Toward Longevity Supplements

The increasing interest in longevity supplements is driven by a growing understanding of ageing mechanisms, such as telomere shortening and mitochondrial decay, and a desire to enhance the quality of life. This trend reflects a broader shift towards preventive healthcare and personalised nutrition.