NMN Side Effects: Everything You Need To Know

What Is NMN?

Common NMN Side Effects

While NMN is generally considered safe, some users have reported mild side effects. These may include:

• Nausea: Some individuals may experience mild stomach discomfort or nausea when taking NMN supplements.
• Bloating: Gastrointestinal bloating has been noted in certain cases, possibly due to the body’s adjustment to the supplement.
• Skin Issues: Mild skin reactions, such as itching or increased sweating, have been found in some users.

These side effects are typically very mild and usually diminish as the body adapts to the supplement.

If any of these symptoms persist or become bothersome, it’s advisable to stop NMN use and consult a healthcare professional. These side effects are based on oral administration of NMN.

Rare But Possible Side Effects Of NMN

Although uncommon, there have been reports of slightly more severe side effects associated with taking NMN.

Some individuals have reported neurological symptoms after long-term use, including:

• Muscle Twitching and Weakness: Some users have experienced muscle fasciculations and a sense of weakness.
• Speech Difficulties: There have been reports of challenges in articulation and communication.
• Brain Fog: A few individuals reported cognitive impairments, such as confusion or difficulty concentrating.

It’s important to note that these reports are anecdotal and not widely documented through many of the clinical studies surrounding NMN. 

Nonetheless, if such symptoms occur, we always recommend discontinuing NMN supplementation and seeking immediate medical attention to rule out other underlying conditions.

Interactions with Medications

While NMN supplementation has been found to offer many potential health benefits, it’s also important to be aware of possible interactions with certain medications.

For example, NMN may interact with blood thinners, diabetes medications, and blood pressure medications.

Supplementing NMN on these medications could potentially alter their effectiveness or increase the risk of side effects.  

Consulting your healthcare provider before starting NMN, provides the peace of mind of receiving personalised advice and knowing you can safely incorporate NMN into your wellness routine without compromising your health.

What Are The Potential Benefits Of NMN?

Research into NMN has highlighted several potential health benefits, including its anti-ageing properties and longevity support:

• Enhanced Energy Metabolism: By increasing NAD+ levels, NMN may boost cellular energy production, leading to improved physical performance and reduced fatigue. [2]
• Improved Insulin Sensitivity: Studies suggest that NMN supplementation can enhance insulin sensitivity, which may be beneficial for metabolic health. [3]
• Cardiovascular Support: NMN has been shown to improve heart function, potentially offering protective benefits against cardiovascular diseases. NMN can also improve blood flow and enhance vascular health. [4]
• Neuroprotection: Animal studies indicate that NMN may have protective effects against age-related cognitive decline by supporting neuronal health. [5]
• Skeletal Muscle Function: NMN can enhance insulin sensitivity and metabolic health by improving oxidative metabolism in skeletal muscles, particularly in contexts such as ageing and prediabetes. [6]

These findings are extremely promising, but it’s essential to approach them with optimism. Extensive studies are still underway, and more research is continuously being published, but it's important to note that some studies have been conducted on animals, and more extensive human trials are needed to confirm these benefits conclusively.

NMN Supplementation - Can It Help With Age-Related Diseases?

Incorporating an NMN supplement into a daily routine is often achieved through supplementation. Dietary sources of NMN, such as edamame, broccoli, cabbage, cucumber, and avocado, contain only small amounts, making it difficult to reach higher levels of NMN through diet alone.

Supplementation offers a convenient and efficient method to elevate NAD+ levels. Daily NMN capsules can seamlessly integrate into a morning routine, ensuring consistent intake.

Bundles like the Naturecan NMN & Resveratrol bundle combine NMN with resveratrol, a polyphenol known for its antioxidant properties, potentially enhancing the overall benefits.

NMN vs. NR

NMN and NR are both precursors to NAD+, but they follow different pathways to boost NAD+ levels in the body. NMN is converted into NAD+ through a more direct route, while NR is first converted into NMN before becoming NAD+.

Both supplements have shown promise in increasing NAD+ levels and supporting overall health, but their relative effectiveness is still under investigation. Some studies suggest that NMN may offer a more efficient way to elevate NAD+ levels due to its direct conversion pathway.[7]

However, more research is needed to determine which supplement is more effective for specific health outcomes. Understanding these differences can help you choose the right supplement to meet your health needs.

Can You Minimise Any Side Effects Of NMN?

There are several strategies to minimise or prevent NMN-related side effects, including:

• Starting with a Low Dose: Gradually increasing NMN intake allows the body to adjust and reduces the likelihood of side effects. Starting with a low dose can help the body adjust.
• Taking NMN with Food: Consuming NMN with meals may help reduce gastrointestinal discomfort.
• Staying Hydrated: Drinking sufficient water can help the body metabolise NMN more efficiently.
• Choosing High-Quality Supplements: Opting for reputable brands ensures purity and minimises the risk of contaminants that could cause adverse effects.

The Best Way To Take NMN For Energy Metabolism

To maximise NMN’s benefits while minimising side effects, consider the following guidelines:

• Take NMN in the Morning: NAD+ levels naturally fluctuate throughout the day, and taking NMN in the morning may align with the body’s circadian rhythm.
• Pair NMN with Resveratrol: Some research suggests that combining NMN with resveratrol may enhance its benefits. [8]
• Follow Recommended Dosages: Adhering to dosage guidelines and professional recommendations can optimise results.

Foods with NMN

NMN is naturally present in various foods, including cabbage, broccoli, edamame, cow’s milk, and cucumbers. While incorporating these foods into your diet can contribute to your NMN intake, the amounts found in food are typically not sufficient to provide significant or noticeable health benefits.

For those looking to achieve therapeutic levels of NMN to support NAD+ production and overall health, NMN supplements may be a more effective option.

FAQs About NMN

Conclusion

While NMN supplementation offers promising health benefits, it is always essential to consider potential side effects. Most side effects are mild and temporary, and many people won't experience any side effects at all, but rare cases of more severe symptoms warrant caution.

By starting with a low dose, staying hydrated, and choosing high-quality supplements, wellness enthusiasts can optimise their experience with NMN and promote longevity.For those looking to support longevity and overall wellness, NMN may be a valuable addition to a health regimen, particularly as part of the growing trend in anti-ageing health products.

However, consulting with a healthcare professional before starting supplementation is always advisable.