By Becky Burrows · Reviewed by Paul Holmes · Updated 3 September 2026
Search for "longevity mix" and you will land on products including Bryan Johnson's Blueprint, IM8, NOVOS, DoNotAge and Naturecan [1,2,3,4]. They're marketed around a similar idea, but their formulas, evidence, prices and regulatory positions differ substantially. Most existing coverage either reviews one of these products in isolation or lists generic longevity supplements without showing what a buyer is actually choosing between [5,6,7].
Below is a direct, side-by-side ranking of all five, including Naturecan's own mix, built on disclosed ingredients, finished-product evidence, price and practicality, not marketing language. Further detail on ingredients, evidence and safety follows underneath. If you want the wider context around Blueprint rather than just this one product, see our Bryan Johnson Supplements 2026 blog.
Naturecan
Longevity Mix
Ten fully disclosed actives per scoop, including 250mg NMN, 250mg trans-resveratrol and 500mg Ca-AKG, with UK stock and no import wait.
Shop Longevity MixIn this article
Longevity Mixes Ranked - Best Price Value
Prices are indicative and change with exchange rates, subscriptions, promotions and shipping. Check the live product page before buying.
🏆 #1 Top Pick
Naturecan Longevity Powder Mix
Best for overall price value£44.99 (30 servings, one 5g scoop daily) [8]
✅ Formula & dosing: Ten actives fully itemised per scoop, including 250mg NMN, 250mg trans-resveratrol, 500mg Ca-AKG and 2g glycine, with no proprietary blend hiding exact amounts [8].
⚠️ Finished-product evidence: No controlled human trial of the finished blend is cited on the listing. Blueprint, IM8 and Naturecan do not cite a controlled trial of their finished mixes. NOVOS and DoNotAge now report controlled finished-product trials; NOVOS's manuscript remains under peer review, while DoNotAge publishes small brand-hosted reports rather than a peer-reviewed paper [2,3,4,8,11,27].
✅ Third-party testing: Naturecan confirms the Longevity Mix is third-party tested; check the current listing for the latest testing documentation [8].
✅ Price & format: Works out as the lowest cost per day in this comparison, with direct UK stock and no import or customs wait [8].
Verdict: The strongest pick here for a fully disclosed formula, straightforward UK buying and value, not a claim of superior health outcomes.
2. Blueprint Longevity Mix
Best for a non-NMN formula~£52.44 (30 servings) [4]
✅ Formula & dosing: 13 actives with quantities disclosed, including creatine, Ca-AKG, taurine and glutathione. Contains no NMN or NR [4].
⚠️ Finished-product evidence: No controlled trial of the finished mix is cited; individual ingredients have separate research at comparable doses [4].
✅ Third-party testing: States third-party testing for purity and heavy metals, and is vegan and non-GMO [4].
✅ Price & format: Lower indicative cost than IM8, NOVOS or DoNotAge, though it's one part of Bryan Johnson's much wider protocol, not equivalent to following it in full [4].
Verdict: A transparent, tested option for readers who want a non-NAD+ recovery blend, at a lower price than the other branded mixes.
3. NOVOS Core
Best for emerging finished-product research$109 per 30 days [2]
✅ Formula & dosing: 12 ingredients with every dose now printed on the label, in three flavours. NMN is sold separately as NOVOS Boost, not included in Core [2].
⚠️ Finished-product evidence: Reports a randomised, double-blind, placebo-controlled trial ("STAMINA," NCT06145087) in adults over 40, measuring flow-mediated dilation. It's the strongest finished-product study claim in this comparison, but the manuscript is still under peer review and hasn't been independently confirmed [2,11].
✅ Third-party testing: States cGMP manufacture and third-party testing on its listing [2].
⚠️ Price & format: The lowest advertised price requires committing to 12 boxes upfront [2].
Verdict: The strongest emerging evidence base of the five, with the caveat that the key study hasn't completed peer review.
4. DoNotAge Routine
Best advanced formulaFrom $203 per 4-week cycle (~$7.25/serving) [3]
✅ Formula & dosing: All 15 ingredients and their per-sachet doses are displayed on the current product label, including 1,000mg NMN, 1,000mg TMG, 800mg Ca-AKG, 500mg trans-resveratrol and 8mg spermidine [3].
⚠️ Finished-product evidence: DoNotAge reports a 28-day randomised, double-blind, placebo-controlled trial in which 19 participants completed the study; whole-blood NAD+ rose by an average of 76% in the treatment group [27]. A second small trial measured self-reported well-being and fatigue [27]. These brand-hosted reports are useful but have not established slower ageing, longer life or reduced disease risk.
⚠️ Third-party testing: Not stated on the reviewed listing for this product [3].
⚠️ Price & format: The highest displayed price in this comparison, and its money-back guarantee requires six months of continuous use plus NAD+ tests before and after [3].
Verdict: The broadest ingredient list and the highest price of the five. The main limitation is that the finished-product evidence is small, brand-hosted and focused on NAD+ plus subjective well-being and fatigue rather than validated ageing outcomes.
5. IM8 Daily Ultimate Longevity
Best for sport certification£149 per 30 days [1]
✅ Formula & dosing: Ten disclosed compounds per sachet, including 300mg NMN, 250mg trans-resveratrol and 3mg spermidine, all fully quantified [1].
⚠️ Finished-product evidence: No controlled trial has been run on this specific longevity powder. The registered trial referenced in IM8's marketing (NCT06655597) covers a different product, Daily Ultimate Essentials [1,10].
✅ Third-party testing: NSF Certified for Sport, an independently checkable batch certification [1,9].
⚠️ Price & format: Higher recurring cost than Naturecan's UK listing, and sold in a single flavour [1].
Verdict: Best suited to buyers who specifically want sport-safety certification and don't mind paying a premium for it.
Overall, Naturecan comes out on top by offering the strongest balance of evidence-led ingredients, transparent dosing, rigorous quality standards and price value. Rather than relying on an excessively long ingredient list or research linked to a different product, Naturecan provides a focused, clearly formulated longevity mix designed for practical daily use [1,2,3,4,11].
For a broader shortlist beyond these four specific brands, see our 8 Best Longevity and Anti-Ageing Supplements blog.
What's Actually Inside Each Formula
Longevity mixes tend to draw from a handful of well-studied ingredient categories: NAD+ precursors like NMN, polyphenols such as resveratrol and fisetin, and compounds associated with clearing senescent cells ("senolytics"). Each category has a reasonable evidence base on its own [12,13,14], but what differs between brands is which categories they include, at what dose, and how transparently they disclose it.
👉 Swipe or scroll sideways to compare each brand's full formula
Brand formula
Naturecan
Naturecan's listing gives a fully itemised 5g serving: 2g glycine, 500mg Ca-AKG, 250mg vitamin C, 250mg magnesium bisglycinate, 250mg trans-resveratrol, 250mg NMN, 100mg L-theanine, 50mg apigenin, 50mg CoQ10 and 5mg spermidine, alongside flavouring and sucralose [8].
No controlled trial of the finished mix is cited, so its advantage in this comparison is transparency, independent testing and UK access rather than a proven health outcome [8].
Brand formula
NOVOS Core
NOVOS Core now prints every ingredient dose on its label [2]. Ingredients per 15g daily serving: vitamin C 100mg; magnesium 304mg (from magnesium malate); calcium 231mg (from Ca-AKG); glycine 2,000mg; malate 1,700mg; Ca-AKG 1,100mg; glucosamine sulfate 1,000mg; rhodiola rosea extract 300mg; L-theanine 150mg; hyaluronic acid 100mg; fisetin 100mg; ginger root extract 100mg; pterostilbene 50mg; and lithium aspartate 20mg, providing 1mg lithium [2].
Its STAMINA trial (adults 40+, flow-mediated dilation as the primary outcome) is the most rigorous study design in this comparison, but until the manuscript clears peer review it should be described as brand-reported rather than independently confirmed [2,11]. A separate 12-person case study using an epigenetic clock is exploratory only, since it had no control group [2].
Brand formula
Blueprint
Blueprint contains no NMN or NR. Ingredients per 14.8g daily scoop: vitamin C 250mg; calcium 400mg (from Ca-AKG); magnesium 150mg (as citrate); creatine monohydrate 2,500mg; Ca-AKG 2,000mg; taurine 1,500mg; glycine 1,200mg; L-lysine HCl 1,000mg; glucosamine sulfate KCl 750mg; reduced L-glutathione 250mg; L-theanine 200mg; and sodium hyaluronate 120mg [4].
The remaining label components are carbohydrate and flavour ingredients rather than additional longevity actives. It is a recovery and antioxidant blend rather than a NAD+-targeted formula. Blueprint discloses quantities and third-party contaminant testing but not a controlled finished-product trial; the powder is only one part of Bryan Johnson's wider protocol [4].
Brand formula
DoNotAge Routine
DoNotAge Routine displays all 15 doses per daily sachet: glycine 2,000mg; SIRT6Activator® 1,600mg; NMN 1,000mg; TMG 1,000mg; Ca-AKG 800mg; trans-resveratrol 500mg; Nitralis® 400mg; quercetin 400mg; magnesium bisglycinate 250mg; vitamin K2 (MK-7) 120µg; vitamin D3 50µg; SulforaBoost® 230mg; high-molecular-weight hyaluronic acid 200mg; CoQ10 200mg; and spermidine 8mg [3].
Its 28-day placebo-controlled study reported a 76% average increase in whole-blood NAD+ among completers [27]. That is evidence for a biomarker change, not proof that the routine slows ageing or improves lifespan, disease risk, cognition or cardiovascular outcomes. A second small study used subjective well-being and fatigue scores [27].
Brand formula
IM8
IM8's ingredients per daily sachet are fully disclosed: glycine 3,000mg; taurine 2,000mg; trans-resveratrol 250mg; quercetin 250mg; fisetin 100mg; NMN 300mg; PQQ 10mg; dihydroberberine 100mg; astaxanthin 6mg; and spermidine 3mg [1]. The page markets this formula as targeting "all 12 hallmarks of ageing" [1].
The hallmarks framework is established biology [15], but IM8 has not shown that this specific blend changes all 12 hallmarks in humans. The registered trial cited in IM8's materials is for Daily Ultimate Essentials, a different product, so it cannot evidence the longevity powder [1,10].
Shared vs. proprietary ingredients
NMN appears in Naturecan, IM8 and DoNotAge. Polyphenols such as resveratrol, quercetin and fisetin turn up in several competing formulas, and Ca-AKG is used by Naturecan, NOVOS, DoNotAge and Blueprint. All five brands publish per-ingredient quantities on their current labels or listings [1,2,3,4,8]. The useful comparison is therefore: which active categories they cover, how the daily doses and formats differ, what each costs, and whether research tests the finished mix or only its individual ingredients.
Evidence Check: Which Claims Actually Hold Up?
In the UK, marketing claims about a food supplement's health benefits have to comply with the Advertising Standards Authority's CAP Code, which requires health-related claims to be backed by robust evidence [16]. That's the standard the claims below are measured against.
| Claim | Brand(s) making this claim | What the published evidence shows | Verdict |
|---|---|---|---|
| Targets all 12 hallmarks of ageing | IM8, NOVOS, DoNotAge | The hallmarks framework is established biology [15], but no controlled finished-product human trial tests any of these blends against all 12 hallmarks [1,2,3]. | Not a demonstrated outcome |
| NMN raises blood NAD+-related measures | Naturecan, IM8, DoNotAge [1,3,8] | Short human trials using roughly 250 to 900mg daily report measurable NAD+ biomarker changes [12,17]. | Reasonable biomarker support |
| NMN extends human lifespan | IM8, DoNotAge [1,3] | No human lifespan trial exists among the cited NMN research [12,17]. | Not established |
| NOVOS's epigenetic-age reduction | NOVOS [2] | The cited case study involved 12 people with no control group [2]. | Exploratory only |
| Fisetin or quercetin as a proven senolytic | IM8, DoNotAge (fisetin and quercetin); NOVOS (fisetin only, not quercetin) [1,2,3] | Small disease-specific pilot studies exist [14,18], but none tests a consumer longevity-mix dose in healthy adults. | Promising mechanism, not proof for a consumer powder |
| Resveratrol supports healthy ageing | IM8, DoNotAge (NOVOS uses pterostilbene instead of resveratrol) [1,3] | Human findings vary by population, dose and outcome measured [13]; the EU's own authorisation caps supplement use at 150mg per day for adults [19]. | Inconsistent, and outcome- and dose-specific |
Price, Dosing & Practicality Compared
Beyond ingredients, the day-to-day reality of using one of these products, cost, format and how it fits your routine, is where most buying decisions actually get made.
| Product | Price | Serving | Notes |
|---|---|---|---|
| Naturecan | £44.99 at source review | 1 scoop, 30 servings | UK fulfilment; market-specific ingredient legality still needs checking [8] |
| IM8 | £104 to £149 | 1 powder sachet daily | Check UK shipping and the live exchange rate [1] |
| NOVOS Core | About £95, NMN separate | 1 powder sachet daily | Direct and retailer availability varies [2] |
| DoNotAge Routine | About £165 to £200 | 1 daily sachet | Continuity terms and destination shipping vary [3] |
| Blueprint | About £50 | 1 scoop daily | Check import costs, duties and live stock [4] |
Taste and mixability are worth a caveat: brand descriptions aren't independent testing, and this comparison didn't run a blinded taste test. IM8 describes an açaí and pomegranate flavour, and Blueprint describes a tangy blood-orange drink; your own experience may vary with water volume and personal preference [1,4].
Practical checks before adding any mix
- Compare the full daily dose, not just the number of ingredients on the label.
- Check for overlapping NMN, resveratrol, magnesium and caffeine across every supplement you already take, since combining a longevity mix with a separate NMN capsule or a super greens powder can mean taking several times the intended dose without realising it.
- Stacking multiple NAD+ precursor products can push your total intake above the level EFSA has assessed as safe, 300mg per day for adults [20].
- Treat third-party testing as a quality-control signal, not evidence that a product slows ageing.
- Check whether the specific ingredient, source, dose and format are legally permitted to sell in your market.
Side Effects, Safety & Who Should Be Cautious
Most reported side effects across this category are mild and dose-related rather than serious. NAD+ precursors like NMN can cause nausea or mild digestive upset in some people, particularly at higher doses, though no serious adverse events have been reported in the published human trials reviewed here [12,17]. Magnesium-containing formulas can have a laxative effect at intakes above 400mg per day from supplements [21]. If you're also taking a separate greens powder alongside a longevity mix, check your combined totals, since some super greens powder formulas add meaningful amounts of magnesium and caffeine on top.
Who should be cautious or speak to a doctor first
- Pregnant or breastfeeding women. EFSA's own safety opinion on NMN explicitly excludes this group from its conclusions [20], and NHS guidance on supplements in pregnancy recommends caution with anything new [22].
- Anyone on anticoagulant medication such as warfarin. Resveratrol has been shown to stereoselectively affect warfarin's pharmacokinetics and enhance its anticoagulant effect [23], which is also why the EU's own authorisation for resveratrol requires a medication-supervision warning on the label [19].
- Anyone with existing NAD+ or niacin sensitivity, or already taking other supplements containing high-dose B vitamins.
UK and EU regulatory status: what the evidence allows us to say
Great Britain: novel foods must be authorised before they're placed on the market. A product appearing in an application register is not the same as an authorised product; check the FSA's authorised novel food guidance and the conditions attached to any entry before assuming a product is fully cleared [24].
European Union and Northern Ireland: EFSA concluded that one specified, chemically synthesised β-NMN ingredient, at least 99% pure, is safe at up to 300mg per day for adults other than pregnant and lactating women [20]. That scientific opinion is not itself market authorisation; the ingredient still needs to appear on the applicable EU Union list of novel foods before it can be marketed on the strength of that opinion [25]. Nicotinamide riboside chloride is a separate, already-authorised novel food and doesn't establish authorisation for NMN [26].
Trans-resveratrol: EU rules permit up to 150mg per day in adult food supplements and require a medication-supervision warning on the label [19]. Both IM8's and Naturecan's formulas use 250mg per serving, above this reference threshold, so it's worth knowing before deciding how much to take alongside anything else [1,8,19]. None of this makes NMN or resveratrol illegal to buy or use, but the regulatory picture is still moving. This isn't medical advice, and none of the products discussed here are intended to diagnose, treat or replace medical care; speak to a pharmacist or GP if you're on medication or have an existing health condition.
Where Naturecan's Longevity Mix Fits
£44.99
30 servings
10
fully disclosed actives
✅
Third-party tested
🇬🇧
UK stock, no import wait
Naturecan's UK listing combines a £44.99 price, 30 servings and a fully itemised ten-active formula: 250mg NMN, 250mg trans-resveratrol, 500mg Ca-AKG, 2g glycine and stated quantities for every other named active [8]. That makes it unusually easy to compare without relying on a proprietary blend.
On the practical measures used in this comparison, Naturecan comes out ahead for a UK buyer who wants a direct UK storefront, a clearly stated price, one-scoop dosing, independent testing and transparent quantities [8]. IM8 offers the stronger sport-certification distinction [1,9]; NOVOS has the strongest emerging finished-product study claim, though its manuscript remains under peer review [2,11]; DoNotAge reports the highest NAD+ biomarker rise but at the highest price [3,27]; and Blueprint offers a non-NMN, recovery-focused alternative [4]. The listing doesn't cite a controlled human trial of the finished mix [8], and its 250mg trans-resveratrol content sits above the EU's 150mg reference threshold, worth checking against the rules that apply in your market [19]. NMN's status should also be checked separately for Great Britain, Northern Ireland and any EU market you're buying into [20,24,25].
For a single daily powder, see the Longevity Mix Powder. If your main goal is simply NAD+ support, the standalone NMN Supplement may suit better than a multi-ingredient mix, while the Complete Longevity Bundle and Healthy-Ageing Longevity Bundle offer broader ready-made formats for readers who want more than one mix provides. If you're weighing this category against a general super greens powder or an AG1 alternative for everyday micronutrient coverage rather than a targeted longevity supplements approach, those are genuinely different product categories, not interchangeable options. Browse the full Longevity collection to compare formats directly, and if terms like Ca-AKG, senolytic or epigenetic clock are new to you, the Longevity Glossary explains them in plain English.
A buyer-focused decision framework
NOVOS reports a registered controlled finished-product trial with a manuscript still under peer review [2,11]. DoNotAge reports two small randomised, placebo-controlled finished-product studies on its own science page, one objective NAD+ biomarker study and one subjective well-being/fatigue study, but neither is a peer-reviewed demonstration of a validated ageing outcome [27]. IM8, Blueprint and Naturecan do not cite comparable finished-mix trials [1,4,8].
All five brands itemise their current formulas and doses [1,2,3,4,8]. Readers should compare the actual daily quantities and serving formats, then separate label transparency from evidence that the finished mix improves meaningful health or ageing outcomes.
Verify that any certificate applies to the exact product and batch you're buying. IM8 has NSF Certified for Sport status [1,9]; NOVOS, Blueprint and Naturecan all state that their products are third-party tested, though Naturecan's Certificate of Analysis had not yet been published at the time of writing [2,4,8]. Testing supports identity and quality control, not longevity efficacy.
Check the ingredient, permitted dose, target population and required warnings for your country of purchase. NMN needs market-specific verification [20,24,25], and trans-resveratrol carries its own EU dose and warning requirements [19].
Compare the live price and routine burden. Naturecan sits at £44.99 for 30 servings [8], IM8 from £104 to £119 a month [1], NOVOS from $79 with a 12-box commitment [2], and DoNotAge at $203 per four weeks [3]. Check Blueprint's price and stock live [4].
Naturecan
See the full ingredient breakdown
Fully disclosed dosing, independent testing and UK stock, at the lowest cost per day in this comparison.
Shop Longevity MixConclusion
Choosing between these longevity mixes comes down to three honest questions: what's your budget, what level of evidence are you willing to accept, and do you want a single mix or a fuller protocol in the Blueprint style? None of the five brands has a peer-reviewed controlled trial showing that its finished product improves a validated ageing outcome. NOVOS reports a registered trial with a manuscript under peer review [2,11], while DoNotAge reports two small brand-hosted randomised trials: an objective NAD+ biomarker result and subjective well-being/fatigue outcomes [27]. If dose transparency and cost matter most to you, look at what's actually itemised on the label rather than the ingredient count or the price tag alone. Naturecan's own longevity mix was built on that principle: a fully disclosed, independently tested formula at a lower monthly cost than the other four brands compared here. See the full ingredient breakdown on the Longevity Mix Powder product page before deciding what's right for you.
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Frequently Asked Questions
Is IM8 Daily Ultimate Longevity worth it, and does it have side effects?
IM8 fully discloses its formula, including 300mg NMN and 250mg trans-resveratrol per sachet, and holds NSF Certified for Sport status [1,9]. It doesn't cite a controlled trial of this specific product; the registered trial referenced in its marketing covers a different product, Daily Ultimate Essentials [1,10]. Reported side effects follow its ingredient categories rather than anything IM8-specific: NAD+ precursors like NMN can cause mild nausea or digestive upset in some people, particularly at higher doses [12,17]. At £149 per 30 days, it sits well above Naturecan's £44.99 [1,8].
Is IM8 a legitimate company, and is David Beckham actually involved?
Yes to both, though it is worth separating the business story from the product's evidence base. IM8 was co-founded by David Beckham alongside Prenetics chief executive Danny Yeung, an active founding role rather than a standard paid endorsement deal [9]. In July 2026, IM8 secured $1 billion in growth financing from General Catalyst's Customer Value Fund; this was structured as revenue-share debt rather than an equity investment, and is earmarked mainly for marketing spend rather than product development. That confirms IM8 is a well-funded, genuine business, but it has no bearing on whether Daily Ultimate Longevity itself is backed by finished-product research; see the question above for that.
What are the best alternatives to IM8 Daily Ultimate Longevity?
If you are comparing away from IM8, the closest formulation matches are Naturecan and DoNotAge, since both pair NMN with trans-resveratrol the way IM8 does. Naturecan does this at 250mg of each for £44.99, with full label transparency and UK stock [1,8]; DoNotAge uses higher 1,000mg NMN and 500mg trans-resveratrol doses across a 15-ingredient sachet, at a higher £153 per 28-day cycle [1,3,28]. NOVOS Core and Blueprint are formulated differently rather than being direct swaps: NOVOS sells its NMN separately as NOVOS Boost, so Core alone is not a like-for-like alternative [2], and Blueprint's Longevity Mix contains no NMN or trans-resveratrol at all, built instead around creatine and amino acids [4]. The comparison cards and Evidence Check table above cover doses, pricing and evidence quality for all five side by side.
What does NOVOS Core's biological age test actually show, and is it worth it?
NOVOS's marketing includes a 12-person case study that uses an epigenetic clock to estimate biological age; with no control group, this is exploratory rather than proof the product changes how you age [2]. NOVOS Core's stronger evidence is its STAMINA trial, a registered, placebo-controlled study of the finished product, though the manuscript is still under peer review [2,11]. NMN isn't included in Core; it's sold separately as NOVOS Boost [2]. At around $79 to $109 with a 12-box commitment for the lowest price, it suits readers who prioritise finished-product research over lowest cost [2].
Is DoNotAge worth the higher price compared to NOVOS or IM8?
The UK subscription price is £153 per 28-day cycle [28]. DoNotAge discloses exact doses for all 15 ingredients and reports a small 28-day placebo-controlled trial showing a 76% average rise in whole-blood NAD+ among completers [3,27]. That supports a biomarker effect, not slower ageing or longer life. Naturecan is the lower-cost UK alternative; IM8 adds sport certification; NOVOS has emerging finished-product research; and Blueprint is the non-NMN, recovery-focused option [1,2,4,8,9,11]. The trade-off is therefore price and limited outcome evidence, not dose transparency.
How does Blueprint's protocol differ from a single longevity mix like NOVOS or IM8?
Blueprint's Longevity Mix contains no NAD+ precursor and no senolytic polyphenols; it is a creatine, amino acid and antioxidant blend [4]. Bryan Johnson's broader protocol includes separate diet, exercise and supplement strategies well beyond this product, so buying the Mix alone is not equivalent to following the full regimen. For NMN plus trans-resveratrol, Naturecan or IM8 is the closer alternative [1,8]; DoNotAge supplies a broader, higher-dose NAD+-focused sachet [3]; and NOVOS Core is another non-NMN formula with a different research profile [2,11].
Is AG1 a longevity mix, or just a greens powder?
AG1 and similar super greens powder products are primarily built for general vitamin, mineral and phytonutrient coverage, not formulated around NAD+ precursors or senolytics the way IM8, NOVOS, DoNotAge and Blueprint are [1,2,3,4]. If you're looking for the best greens powder UK stockists carry for everyday nutrition, that's a genuinely different job to a longevity mix, and it's worth treating them as separate categories rather than an AG1 alternative to any of the brands above.
What is NAD+ and why do most of these formulas include a NAD+ supplement ingredient?
NAD+ is a coenzyme every cell needs for energy metabolism and DNA repair, and levels naturally decline with age. Ingredients like NMN are precursors your body converts into NAD+, and human trials confirm they reliably raise blood NAD+ levels [12,17]. What hasn't yet been shown is that raising this one biomarker translates into a longer or measurably healthier life.
Can you take a longevity mix alongside a super greens powder, or is that redundant?
Not entirely redundant; longevity mixes and greens powders usually target different things, but there's often some overlap in vitamin C, magnesium and B vitamins. Check your combined totals for any shared ingredient so you don't unknowingly exceed recommended daily amounts, particularly for magnesium [21].
Is Naturecan's Longevity Mix comparable to these brands?
Yes. Naturecan is directly comparable on formula logic and transparency: it combines NMN, trans-resveratrol and Ca-AKG at fully disclosed doses, with UK stock, independent testing and no import wait [8]. Readers prioritising sport certification may prefer IM8 [1,9]; those prioritising emerging finished-product research may prefer NOVOS [2,11]; DoNotAge offers the broadest high-dose formula [3]; and Blueprint suits readers avoiding an NAD+ precursor [4]. Naturecan's listing does not cite a controlled trial of the finished mix, so its case rests on disclosed dosing, UK access and price rather than clinical superiority [8].
References
- IM8 Health (2026) Daily Ultimate Longevity. Available at: im8health.com/products/longevity (Accessed: 28 August 2026).
- NOVOS Labs (2026) Scientific evidence behind NOVOS and NOVOS Core product information. Available at: novoslabs.com/scientific-evidence-behind-novos/ (Accessed: 28 August 2026).
- DoNotAge (2026) DoNotAge Routine. Available at: routine.donotage.org/donotage (Accessed: 28 August 2026).
- Blueprint (2026) Longevity Mix, Blood Orange. Available at: blueprint.bryanjohnson.com (Accessed: 28 August 2026).
- Davey, M. (2025) 'Longevity supplements are sold as helping prevent ageing. But do they have any long-term benefits?', The Guardian, 9 December. Available at: theguardian.com (Accessed: 28 August 2026).
- Pearce, T. (2024) 'Longevity: The best and worst supplements to slow ageing'. Available at: drtimpearce.com (Accessed: 28 August 2026).
- New York Post (2025) 'Bryan Johnson Blueprint Longevity Mix review'. Available at: nypost.com (Accessed: 28 August 2026).
- Naturecan (2026) Longevity Mix Powder. Available at: uk.naturecan.com/products/longevity-mix (Accessed: 28 August 2026).
- NSF International (2026) IM8 earns NSF Certified for Sport. Available at: nsf.org (Accessed: 28 August 2026).
- ClinicalTrials.gov (2024) Study NCT06655597. Available at: clinicaltrials.gov/study/NCT06655597 (Accessed: 28 August 2026).
- ClinicalTrials.gov (2024) STAMINA study NCT06145087. Available at: clinicaltrials.gov/study/NCT06145087 (Accessed: 28 August 2026).
- Yi, L. et al. (2023) 'The efficacy and safety of β-nicotinamide mononucleotide supplementation in healthy middle-aged adults', GeroScience, 45(1), pp. 29-43. Available at: pubmed.ncbi.nlm.nih.gov/36482258 (Accessed: 28 August 2026).
- Nunes, S. et al. (2024) 'Resveratrol supplementation and clinical outcomes: A systematic review', Nutrients, 16. Available at: pmc.ncbi.nlm.nih.gov/articles/PMC10815776 (Accessed: 28 August 2026).
- Yousefzadeh, M.J. et al. (2018) 'Fisetin is a senotherapeutic that extends health and lifespan', EBioMedicine, 36, pp. 18-28. Available at: pubmed.ncbi.nlm.nih.gov/30279143 (Accessed: 28 August 2026).
- López-Otín, C. et al. (2023) 'Hallmarks of aging: An expanding universe', Cell, 186(2), pp. 243-278. Available at: cell.com (Accessed: 28 August 2026).
- Committee of Advertising Practice (2026) CAP Code, Section 15: Food, food supplements and associated health or nutrition claims. Available at: asa.org.uk (Accessed: 28 August 2026).
- Braidy, N. and Liu, Y. (2023) 'NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis update', Experimental Gerontology, 182, 112284. Available at: pubmed.ncbi.nlm.nih.gov/37619764 (Accessed: 28 August 2026).
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