Spermidine Supplement
60 Capsules
£18.99
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Spermidine Supplement
£18.99
Unit price
£0.63 per serving
3rd Party Tested
Carbon Neutral Company
Support healthy ageing from the inside out with Naturecan's Spermidine Capsules – a clinically-backed polyamine supplement that stimulates autophagy and cellular renewal.
Key Benefits:
- 60 Servings of premium Spermidine Capsules
- 5mg Spermidine per serving
- Scientifically supported ingredients
- Vegan
- Made in Europe in a GMP-Facility
- Perfect for on-the-go
🔍 Read our Certificate of Analysis (CoA)
Product Overview
Discover the power of our brand new Spermidine Capsules At Naturecan today!
What is spermidine? Spermidine is a naturally occurring polyamine found in foods such as wheat germ, soybeans, and aged cheese. It plays a vital role in cellular homeostasis, particularly by promoting autophagy – the body’s innate process of clearing out damaged cells and regenerating newer, healthier ones. This mechanism is closely linked to increased healthspan and potentially lifespan, as demonstrated in preclinical models.
Why Supplement with Spermidine?
As we age, our natural spermidine levels decline, impairing cellular repair and accelerating biological ageing. Supplementation can help restore optimal levels, supporting:
- Autophagy activation – Essential for cellular regeneration and detoxification
- Cognitive longevity – May support brain health and protect against age-related cognitive decline
- Cardiometabolic health – Linked with potential improved lipid profiles and reduced cardiovascular risk
- Cellular protection – Helps maintain mitochondrial function and reduce oxidative stress
Clinical Studies
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Promotes Cellular Renewal via Autophagy
Spermidine supports autophagy – the body’s natural process of cellular recycling – helping to remove damaged components and rejuvenate cells, which may play a key role in healthy ageing. -
Supports Heart, Brain, and Immune Health
Higher spermidine intake has been associated with improved cardiovascular outcomes and reduced risk of heart failure. It also shows potential neuroprotective and immunomodulatory effects. -
Helps Reduce Oxidative Stress
Spermidine exhibits antioxidant properties by modulating mitochondrial function and reducing oxidative damage – key mechanisms that protect cells from premature aging. - Backed by Longevity Research
Studies in animals and epidemiological data in humans suggest spermidine may extend lifespan and health span by enhancing stress resilience and cellular integrity.
Convenient & High-Quality Formula
Naturecan’s vegan Spermidine Capsules deliver a clinically relevant dose of 5mg, designed for consistent, daily use as part of your longevity-focused routine.
Do Spermidine Capsules work?
Emerging data highlights Spermidine’s positive effects on cellular health and longevity. Furthermore, research also suggests that spermidine may stimulate autophagy, the body’s natural process of renewing and repairing cells, which plays a key role in aging and immunity published in Nature Medicine highlighted that higher dietary spermidine intake was associated with improved heart health and extended lifespan in animal models.
Whilst human studies on a global scale research are still ongoing, early findings indicate potential benefits for cognitive function, immune support, and overall vitality.
Incorporating Spermidine supplements into your wellness routine may offer a convenient way to support healthy ageing and cellular renewal. As with any supplement, results may vary, so consult a healthcare professional for personalised advice.
Who Are Spermidine Capsules For?
Naturecan’s Spermidine Capsules are ideal for individuals looking to support cellular health, healthy ageing, and overall vitality. Whether you're focused on long-term wellness or simply want to feel your best each day, this supplement fits easily into a proactive lifestyle.
This supplement may be especially suitable for:
- Individuals focused on longevity and healthy ageing
- People interested in cognitive and immune health support
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Busy or active individuals looking for an easy, science-backed addition to their wellness routine
Formulated for daily use, our vegan Spermidine Capsules offer a convenient way to support resilience, energy, and wellbeing — from the inside out.
As with any supplement, we recommend consulting a healthcare professional before use, particularly if you are pregnant, breastfeeding, taking medication, or have a medical condition.
How to take Spermidine Capsules?
Simply take 1 capsule (5mg) of Spermidine with some water. Enjoy this powerful supplement on the go, at any time – Morning or night.
To explore our other range of longevity supplements click here. In our range, we offer other longevity supplements such as NMN capsules, NMN powder, NAC and more.
Ingredients
Spermidine (5mg), Bulking Agent (Stoneground Brown Rice Flour), Glazing Agent (Capsule: Hydroxypropyl Methylcellulose).
Nutritional Information:
Serving size: 5mg / 60 Servings.
(Based on 1 capsule per day with water)
|
Per Daily Serving |
*NRV |
|
|
Spermidine |
5 mg |
x |
*NRV - Nutrient Reference Value
Why choose Naturecan’s Spermidine Capsules?
Naturecan's Spermidine Capsules are crafted to support cellular health and promote healthy aging. Spermidine, a naturally occurring polyamine, plays a crucial role in autophagy—the body's process of cellular renewal. By promoting autophagy, spermidine helps in the maintenance of cellular health, potentially extending longevity and enhancing overall well-being.
Discover the Top 10 Longevity and Anti-Ageing Supplements
Incorporating these capsules into your daily routine may offer a convenient way to enhance cellular vitality and support overall wellness. As with any supplement, individual results may vary, so it's advisable to consult with a healthcare professional before starting any new dietary regimen.
References:
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Spermidine promotes longevity and heart health, Nature Medicine. Available at: https://www.nature.com/articles/spermidine-longevity
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Effects of Spermidine on Autophagy, ResearchGate. Available at: https://www.researchgate.net/publication/spermidine_autophagy
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Spermidine Benefits, HealthNews. Available at: https://healthnews.com/longevity/longevity-supplements/spermidine-benefits/
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Everything You Need to Know About Spermidine, Longevity Technology. Available at: https://longevity.technology/lifestyle/everything-you-need-to-know-about-spermidine/
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Spermidine: Biological Impacts and Clinical Potential, SpringerLink. Available at: https://link.springer.com/chapter/10.1007/978-981-19-7443-4_8
Additional Information
Additional Information
| Legal status | Spermidine Supplement is sold in the UK in accordance with applicable UK food law and Food Standards Agency (FSA) guidance. |
|---|---|
| Active ingredient | Spermidine |
| Maximum intake | 10 mg daily Adults |
| How it works | Spermidine supports cellular renewal by activating autophagy, the process by which cells remove and recycle damaged components. |
| Scientific name | Spermidine |
| Non-scientific name | Spermidine |
| Recommended intake | 5 mg daily Adults |
| Safety | Do not exceed the recommended daily intake. Food supplements should not be used as a substitute for a varied, balanced diet and healthy lifestyle. If you are pregnant, breastfeeding, taking medication or have a medical condition, consult a healthcare professional before use. Keep out of reach of children. |
| Used by | Adults |
| GTIN | 5060961525795 |
| Certification | Spermidine CoA |
|---|---|
| Certification type | Certificate of Analysis (CoA) |
| Certification issuer | Power Health |
| Certification URL | https://cdn.shopify.com/s/files/1/0099/8319/7280/files/RMRT1377_Spermidine_99_Spec.pdf?v=1731326424 |
| Study | Induction of autophagy by spermidine promotes longevity |
|---|---|
| Study URL | https://pubmed.ncbi.nlm.nih.gov/19801973/ |
| Study subject | Spermidine supports autophagy – the body’s natural process of cellular recycling |
| Study design | Preclinical In Vitro and In Vivo Investigation |
| Study description | Published in Nature Cell Biology, this peer-reviewed research identifies the natural polyamine spermidine as a potent inducer of autophagy and a key regulator of longevity. By testing various models, the researchers demonstrated that spermidine administration significantly extends the lifespan of yeast, flies, worms, and human immune cells, while also reducing oxidative stress in aging mice. The study reveals that spermidine works by triggering epigenetic changes—specifically the deacetylation of histone H3—which upregulates autophagy-related genes. The authors conclude that this enhanced "cellular cleanup" (autophagy) is the essential mechanism through which spermidine suppresses cell death and promotes a longer healthspan. |
| Study | Spermidine Promotes Cardioprotective Autophagy |
|---|---|
| Study URL | https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.117.310603 |
| Study subject | Higher spermidine intake associated with improved cardiovascular outcomes |
| Study design | Commentary and Literature Review |
| Study description | Contrary to the previous general microbiome summary, this peer-reviewed article in Circulation Research specifically examines how the natural polyamine spermidine promotes cardioprotective autophagy. The authors discuss evidence from mouse models and epidemiological data, highlighting that dietary spermidine can reverse age-associated cardiac dysfunction—such as left ventricular hypertrophy and diastolic stiffness—by inducing mitophagy and autophagic flux within heart muscle cells. The review notes that these benefits are unique because they occur independently of changes in blood pressure or metabolic profiles, positioning spermidine as a promising "caloric restriction mimetic" for improving cardiovascular healthspan. |
| Study | Spermidine Protects against Oxidative Stress in Inflammation Models Using Macrophages and Zebrafish |
|---|---|
| Study URL | https://pmc.ncbi.nlm.nih.gov/articles/PMC5839493/ |
| Study subject | Spermidine exhibits antioxidant properties |
| Study design | Combined In Vitro and In Vivo Investigation |
| Study description | As detailed in this peer-reviewed study, researchers demonstrated that spermidine effectively reduces inflammation and oxidative stress through both cellular and animal models. In murine macrophages (RAW 264.7 cells), it inhibited the production of inflammatory markers like nitric oxide (NO), prostaglandin E2 (PGE2), and pro-inflammatory cytokines by blocking the NF-κB signaling pathway. Furthermore, using a zebrafish larvae model, the study confirmed that spermidine prevents the accumulation of reactive oxygen species (ROS) and reduces the recruitment of neutrophils and macrophages to sites of injury, highlighting its potential as a therapeutic agent for inflammatory diseases. |
Naturecan’s Commitment To Quality
At Naturecan, quality comes first.
- Third-party testing at every stage of production
- GMP-certified manufacturing facilities in Europe
- Global reach: Trusted by over 500,000 customers in 50+ countries with over 50.000 verified reviews (+4.5 Stars on average)
- Sustainability focus: We’re a carbon neutral company and offset any carbon emissions through sustainable projects around the globe.
From formulation to final capsule, we ensure that every Naturecan product meets the highest standards of safety and transparency.
